https://www.lab-liu.com/research daily 0.75 2022-06-22 https://images.squarespace-cdn.com/content/v1/623c80e1d0909333e211512c/ab045097-4c0d-4a43-a80a-32b19e6f70c8/Picture3.jpg Research Morphing Neural Interface Morphing electronics technology can enable longitudinal interrogation of the electrophysiological-neurochemical dynamics during network formation in developing nervous system, beyond the mature nervous system. We aim to develop new tools that interface with single neurons throughout the developmental phase to advance the study of neural circuit formation and neuronal diseases. Morphing electronics enable neuromodulation in growing tissue. Nature Biotechnology 2020. Morphing bioelectronics. Nature Portfolio Bioengineering Community, 2020 https://images.squarespace-cdn.com/content/v1/623c80e1d0909333e211512c/ad9562f9-02c1-4dd8-97d8-1fd7c589a70e/Picture4.jpg Research Precision Bioelectronics Medicine We aim to develop precision electronic medicine that can treat autoimmune and metabolic diseases via organ-specific and personalized neuromodulation, based on feedback from biomolecular signal. Our goal is to use “electrons” instead of “molecules” (pharmaceuticals) to precisely modulate “inflammatory reflex” with high temporospatial resolution. A tissue-like neurotransmitter sensor for the brain and gut, Nature, 606 (7912), 94-101, 2022 Soft and elastic hydrogel-based microelectronics for localized low-voltage neuromodulation, Nature Biomedical Engineering A stretchable neuromorphic efferent nerve with proprioceptive feedback, Nature Biomedical Engineering, 2022 (In press) https://images.squarespace-cdn.com/content/v1/623c80e1d0909333e211512c/f4ddcb95-d88c-4f81-97d3-677a50637a0d/Picture5.jpg Research Medical Wearable Electronics Motion artifact, data accuracy and user comfort are the challenges for medical wearable electronics. We will address the challenges by integrating material design, polymeric microfabrication, electronics and sensing mechanism innovation. 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